DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LORNOXICAM IN 0.75% W/V PVA SOLUTION

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Bannaravuri Thireesha, Dr. Ayya Rajendra Prasad.
The aim of the present work is to develop sensitive, simple, accurate, precise and cost effective UV-spectrophotometric method for the determination of lornoxicam, an non-steroidal anti-inflammatory drug present in0.75% w/v PVA solution. The calibration graph is linear over the range of 618 μg ml-1with a correlation coefficient (r) of 0.9997. The accuracy and precision of the method was evaluated based on intra-day and inter-day variations. The accuracy of the method was further confirmed by standard addition procedure. This developed method is useful for the determination of un entrapped lornoxicam present in 0.75% w/v PVA solution, which is used as external phase in the preparation of micro sponges or micropartciles in quasi - emulsion solvent diffusion method.


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