2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Pulagurtha Bhaskararao*, Gowri Sankar Dannana.
The proposed method was carried out using on an Agilent Zorbax C18 (5μm, 15cm X 4.6mm) column. The composition of Mobile phase containing 0.05 M sodium lauryl sulphate and methanol (95:5 v/v) pH adjusted to 1.84 with orthophosphoric acid, is reported for the simultaneous estimation of Cobicistat & Elvitegravir in pharmaceutical dosage forms has been developed. Operated on isocratic mode at a flow rate of 1.0 ml/min along with 20 μl injection volume. Quantization was achieved by HPLC-UV detection at 265 nm. The developed method is validated over a concentration range 2.45 24.55 μg/mL for Elvitigravir & 2.52 25.22 μg/mL for Cobicistat. The linearity regression coefficient values were found (r2 >0.99).The method is validated as per ICH Guidelines. the proposed developed method was found to be accurate, precisely, reproducible and specific and can be successfully applied for the quantitative estimation of elvitegravir and cobicistat pharmaceutical formulations and routine analysis in quality control part.
http://ift.tt/2e84Qup
Κυριακή 16 Οκτωβρίου 2016
DEVELOPMENT AND VALIDATION OF A MICELLAR LIQUID CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF COBICISTAT AND ELVITEGRAVIR IN PHARMACEUTICAL DOSAGE FORM
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