SOLUBILITY AND DISSOLUTION ENHANCEMENT OF FENOFIBRATE: A REVIEW

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Vidhi C. Murarka*, Shubham M. Pai, Purnima D. Amin.
The main objective of compiling this manuscript was to put forth the assorted methodologies applicable for augmenting the solubility and dissolution properties of one of the anti- hyperlipidemic drugs, fenofibrate (FBT). FBT is a drug of the fibrate class. It is a BCS Class 2 chemical entity having poor aqueous solubility (log P value = 5.24) and high gastro-intestinal [GI] permeability. To overcome this limitation various techniques have been introduced over the past few years viz. solid dispersions, derivatization, cyclodextrin complexation, microencapsulation, particle size reduction, self -microemulsifying drug delivery system [SMEDDS], solid lipid nanoparticles [SLNs], mesoporous silica-based drug loading system, mesoporous carbon-based drug loading system, liposomes and microemulsion. This review speaks about the efficiency in enhancing the solubility and bioavailability of FBT by the above listed methods as put forth by various researchers over the past few years and how methods like particle size reduction, SMEDDS and solid dispersions are efficient and industrially feasible.


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