Τρίτη 27 Δεκεμβρίου 2016

Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8 [Chemistry]

Protein lysine methyltransferases (PKMTs) catalyze the methylation of protein substrates, and their dysregulation has been linked to many diseases, including cancer. Accumulated evidence suggests that the reaction path of PKMT-catalyzed methylation consists of the formation of a cofactor(cosubstrate)–PKMT–substrate complex, lysine deprotonation through dynamic water channels, and a nucleophilic substitution (SN2)...

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