Assessment of alveolar bone marrow fat content using 15 T MRI.

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Assessment of alveolar bone marrow fat content using 15 T MRI.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov 21;:

Authors: Cortes ARG, Cohen O, Zhao M, Aoki EM, Ribeiro RA, Abu Nada L, Costa C, Arita ES, Tamimi F, Ackerman JL

Abstract
OBJECTIVES: Bone marrow fat is inversely correlated with bone mineral density. The aim of this study is to present a method to quantify alveolar bone marrow fat content using a 15 T magnetic resonance imaging (MRI) scanner.
STUDY DESIGN: A 15 T MRI scanner with a 13-mm inner diameter loop-gap radiofrequency coil was used to scan seven 3-mm diameter alveolar bone biopsy specimens. A 3-D gradient-echo relaxation time (T1)-weighted pulse sequence was chosen to obtain images. All images were obtained with a voxel size (58 µm3) sufficient to resolve trabecular spaces. Automated volume of the bone marrow fat content and derived bone volume fraction (BV/TV) were calculated. Results were compared with actual BV/TV obtained from micro-computed tomography (CT) scans.
RESULTS: Mean fat tissue volume was 20.1 ± 11%. There was a significantly strong inverse correlation between fat tissue volume and BV/TV (r = -0.68; P = .045). Furthermore, there was a strong agreement between BV/TV derived from MRI and obtained with micro-CT (interclass correlation coefficient = 0.92; P = .001).
CONCLUSIONS: Bone marrow fat of small alveolar bone biopsy specimens can be quantified with sufficient spatial resolution using an ultra-high-field MRI scanner and a T1-weighted pulse sequence.

PMID: 29292160 [PubMed - as supplied by publisher]

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