Oral potentially malignant disorders: risk of progression to malignancy.

Oral potentially malignant disorders (OPMD) have a stastically increased risk of progessing to cancer, but the risk varies according to a range of patient or lesion related factors. It is difficult to predict the risk of progression for any individual patient and the clinician must make a judgement based an assessment of each case. The most commonly encountered OPMD is leukoplakia, but others including lichen planus, oral submucous fibrosis and erythroplakia may also be seen. Factors associated with an increased risk of malignant transformation include gender, the site and type of lesion, habits such as smoking and alcohol and the presence of epithelial dysplasia on histologic examination.

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