Sleep Apnea and Kidney Function Trajectory: Results from a 20-year Longitudinal Study of Healthy Middle-Aged Adults.

Sleep Apnea and Kidney Function Trajectory: Results from a 20-year Longitudinal Study of Healthy Middle-Aged Adults.

Sleep. 2017 Nov 03;:

Authors: Canales MT, Hagen EW, Barnet JH, Peppard PE, Derose SF

Abstract
Objective: To determine whether sleep apnea, defined by polysomnography, accelerates kidney function decline in generally healthy adults not selected for sleep apnea or kidney disease.
Methods: We performed a retrospective cohort study 855 participants from the Wisconsin Sleep Cohort Study (WSCS), a large 20-year population-based study of sleep apnea, who had at least one polysomnogram and serial measurements of serum creatinine over time. Sleep apnea was defined as an apnea-hypopnea index ≥15 or positive airway pressure (PAP) use at baseline. We compared the slope of estimated glomerular filtration rate (eGFR) change and odds of rapid eGFR decline (>2.2 ml/min/1.73m 2/year) for those with and without sleep apnea.
Results: The mean follow-up was 13.9 ± 3.4 years. The cohort was 50.4 ±7.6 years, 55% male, and 97% White. The mean eGFR was 89.3 ±13.8 ml/min/1.73m2 and 11% had sleep apnea. Overall, the mean eGFR change was -0.88 ± 1.12 ml/min/1.73m2/year. Compared to those without sleep apnea, participants with sleep apnea had a 0.2 ml/min/1.73m2/year slower eGFR decline though this was not statistically significant (95%CI [-0.06 - 0.45], p=0.134). When we excluded those on PAP therapy (n=17), eGFR decline was even slower among those with sleep apnea (0.36 ml/min/1.73m2/year slower, 95%CI [0.08-063], p=0.012). Those with sleep apnea had lower odds of rapid eGFR decline but this was not statistically significant, even after excluding PAP users.
Conclusion: Among healthy middle-aged adults, the presence of sleep apnea at baseline did not accelerate kidney function decline compared to those without sleep apnea over time.

PMID: 29112764 [PubMed - as supplied by publisher]

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