Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity: a preliminary study.

Connection between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity: a preliminary study.

Pol Arch Intern Med. 2017 Nov 07;:

Authors: Bromińska B, Cyrańska-Chyrek E, Kuźnar-Kamińska B, Kostrzewska M, Winiarska H, Sawicka-Gutaj N, Zybek-Kocik A, Hernik A, Wrotkowska E, Krasiński Z, Ruchała M, Batura-Gabryel H

Abstract
INTRODUCTION    There is growing evidence that obstructive sleep apnea (OSA) influences both bone metabolism and structure. Chitinase-3-like protein 1 (YKL-40) is a novel inflammatory and remodeling marker, which was shown to increase in OSA. YKL-40 can probably alter the bone turnover.   OBJECTIVES    Assessment of a possible interplay between YKL-40 and bone turnover markers in patients with different stages of OSA. Evaluation of the relation among bone mass, OSA severity, and YKL-40 level. PATIENTS AND METHODS    The study is based on 72 male OSA patients divided into three groups according to disease severity using apnea-hypopnea index (AHI): OSA 1 n = 18 (5 ≤ AHI < 15), OSA 2 n = 25 (15 ≤ AHI < 30), OSA 3 n = 29 (AHI ≥ 30). All subjects have undergone polysomnography and densitometry. Fasting blood samples were collected for YKL-40, C-terminal telopeptide of type-1 collagen (CTX), Procollagen type 1 N-terminal propeptide (P1NP) and other markers.  RESULTS    P1NP differed between OSA 1 and OSA 2; OSA 1 and OSA 3 (P = 0.02). OSA 2 had higher CTX than OSA 1 (borderline statistical significance P = 0.05). Simple linear regression analysis showed that YKL-40 serum levels were significantly associated with CTX (P < 0.0001, β = 0.9871) and P1NP (P <0.0001, β = 0.9780) levels.  CONCLUSIONS    Our study might suggest that YKL-40 is associated with bone turnover in OSA. We may assume that it influences both bone formation and destruction; thus, OSA could be characterized by preserve BMD.

PMID: 29112186 [PubMed - as supplied by publisher]

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