Insight into Reduction of Wakefulness by Suvorexant in Patients with Insomnia: Analysis of Wake Bouts.

Insight into Reduction of Wakefulness by Suvorexant in Patients with Insomnia: Analysis of Wake Bouts.

Sleep. 2017 Nov 03;:

Authors: Svetnik V, Snyder ES, Tao P, Scammell TE, Roth T, Lines C, Herring WJ

Abstract
Objectives: To examine the duration and frequency of wake bouts underlying the wakefulness-after-sleep-onset (WASO) reduction with suvorexant.
Methods: We analyzed polysomnogram recordings from clinical trials involving 1518 insomnia patients receiving suvorexant (40/30mg, 20/15mg) or placebo to determine: 1) the number of, and time spent in, long or short wake bouts, 2) the association between sleep quality and bout characteristics. We also compared wake and sleep bout characteristics of suvorexant in insomnia patients versus zolpidem in healthy subjects undergoing experimentally-induced transient insomnia.
Results: Relative to placebo, suvorexant decreased the number and time spent in long wake bouts (>2 minutes) and increased the number and time spent in short wake bouts (≤2 minutes). The time spent in long wake bouts during Night-1 decreased by 32-54 minutes, while the time spent in short wake bouts increased by 2-6 minutes. On average, a patient returned to sleep from his/her longest awakening more than twice as fast on suvorexant than placebo. The reduced time spent in long wake bouts resulted in odds ratios of self-reported good/excellent sleep quality ranging from 1.59-2.19 versus placebo. The small increase in time spent in short wake bouts had no effect on odds ratios. Findings were more pronounced for the higher (40/30mg) doses of suvorexant. The wake and sleep bout characteristics of suvorexant differed from zolpidem which equally decreased the number of wake and sleep bouts of all durations during the early part of the night.
Conclusion: Suvorexant reduces WASO by reducing long wake bouts. This reduction has a positive effect on sleep quality.

PMID: 29112763 [PubMed - as supplied by publisher]

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