Viruses, Vol. 9, Pages 323: Protoparvovirus Interactions with the Cellular DNA Damage Response

Viruses, Vol. 9, Pages 323: Protoparvovirus Interactions with the Cellular DNA Damage Response

Viruses doi: 10.3390/v9110323

Authors: Kinjal Majumder Igor Etingov David Pintel

Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. This review explores how protoparvoviruses, and specifically MVM, co-opt the common mechanisms regulating the DDR and cell cycle progression in order to prepare the host nuclear environment for productive infection.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2iN4HjP
via IFTTT