Chitosan-co-Hyaluronic acid porous cryogels and their application in tissue engineering

Publication date: October 2017
Source:International Journal of Biological Macromolecules, Volume 103
Author(s): Tuğçe Kutlusoy, Burcu Oktay, Nilhan Kayaman Apohan, Mediha Süleymanoğlu, Serap Erdem Kuruca
In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid (0, 10, 20, 30 and 50wt% hyaluronic acid) was prepared. Morphological studies showed that the macroporous cryogels have been developed with 90–95% porosity. Particularly, the mechanical and biomaterial property of pure chitosan was improved by making copolymer with hyaluronic acid in different concentration. The MTT cell viability results demonstrated that the cryogels have no significant cytotoxicity effect on 3T3 fibroblast and SAOS-2 cells.

Graphical abstract

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2rHbwmS
via IFTTT