Tumor necrosis factor-alpha and insulin resistance in chronic viral hepatitis B in Makurdi, Nigeria

Ayu Agbecha, Chinyere Adanna Usoro, Maisie Henrietta Etukudo

International Journal of Clinical and Experimental Physiology 2016 3(4):190-196

Background and Aim: Previous studies have reported manifestations other than liver disease in patients with chronic hepatitis B (CHB), with specific reports of incidental type 2 diabetes mellitus. This study aimed at determining the impact of CHB disease on insulin resistance and its correlation with tumor necrosis factor-alpha (TNF-α). Methods: Seventy CHB patients aged 18-55 years attending a tertiary hospital were selected as study group subjects and anthropometrically matched with 65 apparently healthy controls. Blood pressure (BP), body mass index (BMI), TNF-alpha, fasting serum insulin (FSI), fasting plasma glucose (FPG) and homeostasis model assessment of insulin resistance (HOMA-IR) were measured in both study and control group subjects. Results: There was no significant (P > 0.05) difference between the mean systolic blood pressure (BP), diastolic BP, age, and body mass index of CHB and controls. There was a significant (P < 0.05) increase in TNF-α, fasting plasma glucose, and homeostasis model assessment of insulin resistance (HOMA-IR) in CHB than the controls. There was a significant (P < 0.01) direct correlation between TNF-α and HOMA-IR (r = 0.534), TNF-? and fasting serum insulin?(α and fasting serum insulin (r = 0.509) in CHB patients. Conclusion: CHB infection induces insulin resistance with TNF-α mediating the insulin resistance. In terms of effective management, CHB patients may need to be monitored for the occurrence of insulin resistance and diabetes mellitus.

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