The induction of localized pro-inflammatory niches in the periphery is instrumental in metastasis. In order to better understand how tumors engage distal sites and activate a pro-inflammatory response we utilized syngeneic breast cancers as a model and showed that soluble factors from the neoplastic epithelium activate the expression of the monocyte chemoatractive protein (MCP) chemokines of the mouse 11C cluster that include Ccl1, Ccl2, Ccl7, Ccl8, Ccl11 and Ccl12. Tissues such as the lungs and the brain, that are more prone to colonization by breast cancer cells, were more sensitive to MCP cluster chemokine induction than others such as the liver.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2iyMfqG
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Word retrieval is core to language production and relies on complementary processes: the rapid activation of lexical and conceptual represen...
-
Formation of the nucleus–vacuole junction (NVJ) is mediated by direct interaction between the vacuolar protein Vac8p and the outer nuclear e...
-
It is unknown whether the ability to visually distinguish between faces and nonfaces is subject to a critical period during development. Wou...
-
Although the study of medicine and the tradition of medical students gaining clinical experience on hospital wards have not significantly ch...
-
Abstract We present an analytic study to support the understanding of collapsing of glass tubes released by local heating and driven by th...
-
Original Cartoons by Walter J. Pories, MD, FACS Professor of Surgery, Biochemistry and Kinesiology, East Carolina University, Greenville, No...
-
Zusammenfassung Hintergrund Zahlreiche diagnostische und therapeutische Prozeduren erfolgen über Gefäßzugänge. Hierbei können intra- und...
-
Abstract Background Patients with a body mass index (BMI) >35 kg/m 2 who need kidney transplant present with increased postoperative...
-
Abstract Sexual intercourse (vaginal and anal) is the predominant mode of human immunodeficiency virus (HIV) transmission. Topical microbi...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου