2016-12-10T00-22-31Z
Source: Indo American Journal of Pharmaceutical Research
K. Gowri, D. Srinivasulu*, M. Srinivasa Rao, VVPC. Narayana.
A series of new 2-(phenylthio) phenyl substituted carbamate (3a-d) and N-(2-(phenylthio) phenyl substituted sulfonamide derivatives (5a-d) were synthesized from 2-(phenylthio) aniline (1) using various pharmacologically active carbonochloridates (2a-d) and sulfonyl chlorides (4a-d) in the presence of a mild base. The structures of all the newly synthesized compounds were characterized by the IR, NMR (1H & 13C) and mass analysis. Further, all the synthesized compounds were screened for the antimicrobial activity. Among all the tested compounds, 3c and 5b showed potent antibacterial and antifungal activities and these compounds might be used as antibiotic drugs.
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Σάββατο 10 Δεκεμβρίου 2016
SYNTHESIS OF CARBAMATE AND SULFONAMIDE ANALOGUES OF 2-(PHENYLTHIO) ANILINE AND THEIR ANTIMICROBIAL EVALUATION
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