HYPOGLYCEMIC AND LIPID PROFILE IN ALLOXAN INDUCED DIABETIC RATS TREATED WITH GLIBENCLAMIDE, METFORMIN AND TWO POLYHERBAL BITTERS

2016-12-10T02-17-59Z
Source: Indo American Journal of Pharmaceutical Research
Etim, Emmanuel I., Udodok, Idara N., Akwaowoh, Akpabio E., Udo, Nsikan M..
The polyherbal bitters are herbal galenicals commonly used by diabetic patients, because they are claimed to have antidiabetic potentials. Promoters of the bitters claim that, the bitters being of natural origin could be concurrently administered with conventional therapeutic drugs with no adverse effects. This research was aimed at assessing the effect(s) or otherwise of the co-administration of two popular bitters in Nigeria market Swedish bitter (SB) and Yoyo bitters (YB) and two therapeutic antidiabetic drugs metformin (MET) and glibenclamide (GLI) on the hypoglycemic and lipid profile in alloxan induced diabetic rats. Fifty four diabetic rats of both sexes weighing between 160g to 230g were divided into nine groups with six animals per group. Therapeutic doses of the bitters alone and in combination with GLI and MET corresponding to the body weight of the animals were administered orally to the different groups daily for 14 days. After an overnight fast, fasting blood glucose levels were obtained by tail tipping method on days 0, 1, 3, 5, 8, 11 and 14. On the 14th day the rats were sacrificed and blood collected by cardiac puncture. The blood was centrifuged and the plasma collected was analyzed for lipid profile. The results obtained indicated that GLI, MET, SB and YB all caused a significant decrease (p


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