SOLID DISPERSIONS: AN APPROACH TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUGS

2016-12-10T02-17-59Z
Source: Indo American Journal of Pharmaceutical Research
R. Santosh Kumar*, T. Naga Satya Yagnesh.
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. Solid dispersion have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. Most of the newly invented chemical entities are poorly water soluble. As a result formulating them as oral solid dosage forms is a hurdle to the specialists. Many techniques have been exercised to improve oral bioavailability of drugs. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. Different formulation strategies have been taken to prepare solid dispersions. It is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability. This article reviews the various preparation techniques for solid dispersions, carriers used in the formulation of solid dispersions and pharmaceutical applications of solid dispersions which can give an overall knowledge of enhancing the solubility of poorly soluble drugs.


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