FORMULATION AND EVALUATION OF pH TRIGGERED IN SITU OPHTHALMIC GEL OF MOXIFLOXACIN HYDROCHLORIDE

2016-12-10T00-22-31Z
Source: Indo American Journal of Pharmaceutical Research
Hemalata Dol*, Ashok Hajare, Vikram Shinde, Sanket Gandhi, Omprakash Gaja.
Antibiotics are the second most widely prescribed drugs in todays scenario due to the increasing rate of infections. Irrational prescriptions of antibiotics can lead to the emergence of antimicrobial resistance and the present study was carried in our hospital surgery department with the objective to estimate the antibiotic prescribing pattern in surgery department.A prospective and observational study was carried out in 207 patients from October 2014 to March 2015. Relevant information was obtained from the interview as well the treatment chart of patients, by using case report form. Results from the study suggest that majority of the patients enrolled in study were females (72.94%).Among the study population majority were belonging 59-68 years age group (23.1%) in which majority was farmers (59.4%).Most of the subjects were diagnosed with Hernia(21.7%), Appendicitis (14.5%) in which surgery was done for 70.7%. After the treatment (96.1%) of the study population showed improvement and 26% patients had drug-drug interactions in which 20.7% the drug interaction was mild .3.8% of underwent with culture sensitivity test with blood and peritoneal fliud.Cephalosporins (63.8%) and Nitroimidazole (53.1%) were the most commonly prescribed antibiotics. It can be concluded from the study that prescribing pattern of drugs antibiotics needs to be continuously evaluated in surgery department in order to promote the more rational prescribing to decrease morbidity and cost of therapy to the patient.


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