Dopamine D1 and D2 Receptors Make Dissociable Contributions to Dorsolateral Prefrontal Cortical Regulation of Rule-Guided Oculomotor Behavior

Publication date: Available online 30 June 2016
Source:Cell Reports
Author(s): Susheel Vijayraghavan, Alex James Major, Stefan Everling
Studies of neuromodulation of spatial short-term memory have shown that dopamine D1 receptor (D1R) stimulation in dorsolateral prefrontal cortex (DLPFC) dose-dependently modulates memory activity, whereas D2 receptors (D2Rs) selectively modulate activity related to eye movements hypothesized to encode movement feedback. We examined localized stimulation of D1Rs and D2Rs on DLPFC neurons engaged in a task involving rule representation in memory to guide appropriate eye movements toward or away from a visual stimulus. We found dissociable effects of D1R and D2R on DLPFC physiology. D1R stimulation degrades memory activity for the task rule and increases stimulus-related selectivity. In contrast, D2R stimulation affects motor activity tuning only when eye movements are made to the stimulus. Only D1R stimulation degrades task performance and increases impulsive responding. Our results suggest that D1Rs regulate rule representation and impulse control, whereas D2Rs selectively modulate eye-movement-related dynamics and not rule representation in the DLPFC.

Graphical abstract

Teaser

Prefrontal cortical activity controls rule-guided flexible behavior. Vijayraghavan et al. examined the effects of dopamine receptor stimulation on working memory activity for rules guiding eye movements. D1 receptor stimulation deteriorates rule maintenance and increases impulsive responding, whereas D2 receptor stimulation selectively enhances movement-related activity depending on the rule context.


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