Prediction of radiation necrosis in a rodent model using magnetic resonance imaging apparent transverse relaxation ( ##IMG## [http://ift.tt/2rEmm1h] {$R_{2}^{*}$} )

Background and purpose . Radiation necrosis remains an irreversible long-term side-effect following radiotherapy to the brain. The ability to predict areas that could ultimately develop into necrosis could lead to prevention and management of radiation necrosis. Materials and Methods . Fischer 344 rats were irradiated using two platforms (micro-CT irradiator and x -Rad 225 IGRT) with radiation up to 30 Gy for the micro-CT and 40 Gy for the x RAD-224 to half the brain. Animals were subsequently imaged using a 9.4 T MRI scanner every 2–4 weeks for up to 28 weeks using a 7-echo gradient echo sequence. The apparent transverse relaxation constant ( ##IMG## [http://ift.tt/2Gl1Upt] {$R_{2}^{*}$} ) was calculated and retrospectively analyzed. Results . Animals irradiated with the low-dose rate micro-CT did not exhibit any symptoms or imaging changes associated with RN. Animals irradiated wi...

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