Multi-omics integration reveals the landscape of pro-metastasis metabolism in hepatocellular carcinoma [Research]

The systematic investigation of gene mutation and expression is important to discover novel biomarkers and therapeutic targets in cancers. Here, we integrated genomics, transcriptomics, proteomics, and metabolomics to analyze three hepatocellular carcinoma (HCC) cell lines with differential metastatic potentials. The results revealed the profile of the pro-metastasis metabolism potentially associated with HCC metastasis. The multi-omic analysis identified 12 genes with variations at multiple levels from three metabolic pathways, including glycolysis, starch and sucrose metabolism, and glutathione metabolism. Furthermore, UDP-glucose pyrophosphorylase 2 (UGP2), was observed to be persistently up-regulated with increased metastatic potential. UGP2 overexpression promoted cell migration and invasion, and enhanced glycogenesis in vitro. The role of UGP2 in metastasis was further confirmed using a tumor xenograft mouse model. Taken together, the compendium of multi-omic data provides valuable insights to understand the roles of shifted cellular metabolism in HCC metastasis.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2DPBf5w
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