Publication date: Available online 6 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Hoda Abel Mahedi Mohamed, Charlotte Emilie Nor Nielsen, Morten Schiodt
ObjectiveTo report cases of medication related osteonecrosis of the jaws (MRONJ) associated with Targeted Therapy (TT) with and without concomitant anti-resorptive treatment, among The Copenhagen ONJ Cohort, which includes all consecutive cases of MRONJ seen in Copenhagen.Study designWe retrospectively studied the medication of 204 consecutive MRONJ patients, seen between January 2010 and May 2016, in order to identify those associated with TT.ResultsWe detected seven cases of MRONJ associated with TT (3.4 %). Four patients received TT only, whereas three were concomitantly treated with bisphosphonates (n=3) and/or denosumab (n=3). The TT regimens included: sunitinib(Sutent®) (n=1), everolimus(Afinitor®) (n=1), erlotinib(Tarceva®) (n=1), bevacizumab(Avastin®) (n=3), dasatinib(Sprycel) (n=1) and imatinib(Glivec®) (n=1). The MRONJ stage included stage 1 and 2, and mean pain from the jaw was VAS 4.0.ConclusionHealth care providers should be aware of the possibility of MRONJ related to the TT agents sunitinib, everolimus and dasatinib and to patients with uncommon cancer types, including renal cell carcinoma, non-small-cell lung cancer, glioblastoma and leukemia, where MRONJ may also occur.
from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2ycaanf
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation...
-
Abstract Purpose Overcoming the flaws of current data management conditions in head and neck oncology could enable integrated informatio...
-
http://orl-agios.blogspot.com/2017/06/the-preclinical-anticancer-effect-of.html Flavonoids present in foods were considered non-absorbable b...
-
Vol.31 No.5 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k8FKtW via IFTTT
-
Publication date: Available online 24 December 2017 Source: European Journal of Radiology Author(s): Wenbin Jiang, Hongwei Xue, Qinqin W...
-
Geographic region: Does it matter in cutaneous melanoma of the head and neck? Laryngoscope. 2017 Jun 05;: Authors: Kılıç S, Unsal AA,...
-
We report an unusual case of a strangulated internal hernia resulting from a right paraduodenal fossa hernia (PDH) in the context of bowel m...
-
Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex...
-
December from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1luSNqR via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου