A meta-analysis of use of Prostate Imaging Reporting and Data System Version 2 (PI-RADS V2) with multiparametric MR imaging for the detection of prostate cancer

Abstract

Objectives

This meta-analysis was undertaken to review the diagnostic accuracy of PI-RADS V2 for prostate cancer (PCa) detection with multiparametric MR (mp-MR).

Methods

A comprehensive literature search of electronic databases was performed by two observers independently. Inclusion criteria were original research using the PI-RADS V2 system in reporting prostate MRI. The methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Data necessary to complete 2 × 2 contingency tables were obtained from the included studies.

Results

Thirteen studies (2,049 patients) were analysed. This is an initial meta-analysis of PI-RADs V2 and the overall diagnostic accuracy in diagnosing PCa was as follows: pooled sensitivity, 0.85 (0.78–0.91); pooled specificity, 0.71 (0.60–0.80); pooled positive likelihood ratio (LR+), 2.92 (2.09–4.09); pooled negative likelihood ratio (LR–), 0.21 (0.14–0.31); pooled diagnostic odds ratio (DOR), 14.08 (7.93–25.01), respectively. Positive predictive values ranged from 0.54 to 0.97 and negative predictive values ranged from 0.26 to 0.92.

Conclusion

Currently available evidence indicates that PI-RADS V2 appears to have good diagnostic accuracy in patients with PCa lesions with high sensitivity and moderate specificity. However, no recommendation regarding the best threshold can be provided because of heterogeneity.

Key Points

• PI-RADS V2 shows good diagnostic accuracy for PCa detection.

• Initially pooled specificity of PI-RADS v2 remains moderate.

• PCa detection is increased by experienced radiologists.

• There is currently a high heterogeneity in prostate diagnostics with MRI.

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