Effects of single condylar neck fracture without condylar cartilage injury on traumatic heterotopic ossification around temporomandibular joint in mice

Publication date: Available online 6 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Ningjuan Ouyang, Xiaofang Zhu, Hongliang Li, Yuheng Lin, Jun Shi, Jiewen Dai, Guofang Shen
ObjectivesIn this study, we try to explore the effects of single condylar neck fracture without condylar cartilage injury during the pathogenesis process of traumatic heterotopic ossification around temporomandibular joint (THO-TMJ).Study designOne-month-old C57BL/6J male mice were divided into two groups. In group one, condylar cartilage was partially removed in the right joint to induce traumatic heterotopic ossification. In group two, a single fracture on the condylar neck was created using small scissors. The condylar head was repositioned to its original place if any displacement occurred. The phenotypes were observed using gross observation, micro-computed tomography scans and histological examination.ResultsThe results showed obvious hyperplasia in the right condyle in group one, with ectopic bones and cartilage in the periarticular region. In group two, the surface of condyle was smooth, but the size of the right condylar head became smaller.ConclusionsTaking these findings together, it can be concluded that the injured condylar cartilage, while not a single condylar neck fracture without condylar cartilage injury, contributes to the development of THO-TMJ.



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