Osteoblast role in osteoarthritis pathogenesis

Abstract

Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregulation of osteoblast function, bone remodeling and mineralization, leading to osteoarthritis development. Moreover, osteoblasts produce numerous transcription factors, growth factors and other proteic molecules which are involved in osteoarthritis pathogenesis. This article is protected by copyright. All rights reserved

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pG6xlI
via IFTTT