New draft recommendations released on April 11, this year, by the US Preventive Service Task Force (USPSTF) advise men aged 55–69 years to discuss prostate-specific antigen (PSA)-based screening for prostate cancer with their physicians. The change from previous recommendations, published in 2012, that counselled against PSA-based screening in all age groups is informed by two large randomised trials: one conducted in Europe and the other in the USA. The USPSTF concludes that while many men will experience potential harms of screening (false–positive results, overdiagnosis, and overtreatment), screening 1000 men can prevent one to two prostate cancer deaths and may prevent three men from developing metastatic prostate cancer.
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