Immune checkpoint inhibitors targeting the cytotoxic T-lymphocyte-associated protein 4 and programmed cell-death protein 1 (PD-1) pathways have transformed the prognosis of patients with advanced-stage melanoma and other selected cancers. The price of this unique efficacy associates with a frequent opportunistic autoimmunity secondary to immunotherapy (OASI), leading to treatment interruption in a large proportion of patients [1]. Therefore, promoting early recognition and adequate management of OASI is worthwhile [2].
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