Whole Blood Donation Affects the Interpretation of Hemoglobin A1c

by Angelique Dijkstra, Erna Lenters-Westra, Wim de Kort, Arlinke G. Bokhorst, Henk J. G. Bilo, Robbert J. Slingerland, Michel J. Vos

Introduction

Several factors, including changed dynamics of erythrocyte formation and degradation, can influence the degree of hemoglobin A_1c (HbA_1c) formation thereby affecting its use in monitoring diabetes. This study determines the influence of whole blood donation on HbA_1c in both non-diabetic blood donors and blood donors with type 2 diabetes.

Methods

In this observational study, 23 non-diabetic blood donors and 21 blood donors with type 2 diabetes donated 475 mL whole blood and were followed prospectively for nine weeks. Each week blood samples were collected and analyzed for changes in HbA_1c using three secondary reference measurement procedures.

Results

Twelve non-diabetic blood donors (52.2%) and 10 (58.8%) blood donors with type 2 diabetes had a significant reduction in HbA_1c following blood donation (reduction >-4.28%, P 1c. In the non-diabetic group the maximum reduction was -11.9%, in the type 2 diabetes group -12.0%. When eligible to donate again, 52.2% of the non-diabetic blood donors and 41.2% of the blood donors with type 2 diabetes had HbA_1c concentrations significantly lower compared to their predonation concentration (reduction >-4.28%, P Conclusion

Patients with type 2 diabetes contributing to whole blood donation programs can be at risk of falsely lowered HbA_1c. This could lead to a wrong interpretation of their glycemic control by their general practitioner or internist.

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