Nicotinamide reduces COX-2 expression in HaCaT keratinocytes after ultraviolet B irradiation

Abstract

In their interesting research letter, Chen et al. (2016 Apr 8. doi: 10.1111/bjd.14662)¹ described the protective effects of oral nicotinamide (NCT) for chemoprevention of non-melanoma skin cancers (NMSCs) in renal transplant recipients. We totally agree that NCT can represent a new opportunity

for NMSC chemoprevention basing on its capability to preserve cellular energy reserve for ATP-dependent DNA repair as well as UV-induced immunosuppression.² Moreover, we hypothesize that one of the mechanisms through which NCT may act is by modulating the expression of cyclooxygenase (COX)-2, the rate-limiting enzyme in prostaglandin (PG) generation.

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