Ultra-high-performance liquid chromatography tandem mass spectrometry determination of GHB, GHB-glucuronide in plasma and cerebrospinal fluid of narcoleptic patients under sodium oxybate treatment

Type 1 narcolepsy (NT1) is a neurological disorder caused by the loss of orexin (hypocretin) neurons in the lateral hypothalamus, probably due to an autoimmune mechanism. It is characterized by excessive daytime sleepiness (EDS) with sleep attacks, cataplexy episodes, hypnagogic hallucinations, sleep paralysis, and disturbed nighttime sleep patterns [1–4]. Cataplexy, i.e. sudden loss of muscle tone, mostly triggered by strong emotions [5] is a particularly troublesome symptom of NT1.

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