The identification of treatment strategies that could ameliorate or even prevent symptom onset and progression in patients with multiple sclerosis (MS) remains a largely unmet need. Several recent studies have consistently demonstrated that modulation of brain functional plasticity within cognitive-related networks by using, for instance, tailored cognitive-rehabilitation procedures can help to restore cognitive abilities.1 In their JNNP paper, Hulst et al2 investigated the effects of a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex on working memory performance in 17 MS patients without cognitive impairment. Using the N-back task during functional MRI, they also assessed the consequences of rTMS on the recruitment and connectivity within the working memory network. The two main findings of this study are a significant improvement...
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