2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
Satish Polshettiwar, Snehal Shivaji Khorate*.
Solubility is the important phenomenon in pharmaceutical formulation, which plays very effective and significant role in the designing of various dosage forms. It is important characteristics of a drug for its oral bioavailability, formation and development of different dosage form of different drugs and for quantitative analysis. There are many techniques which are used to enhance the aqueous solubility, hydrotropy is one of them which is simple, advance, cost effective, eco-friendly and novel method. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. To achieve highest degree of solubility hydrotropes can be combined with polymers or cosolvents as in mixed hydrotropy. Mixed hydrotropic solubilization technique is the phenomenon to increase the solubility of poorly water-soluble drugs in the blends of hydrotropic agents which gives synergistic enhancement in solubility. Based on advantages of certain properties like the high selectivity, independent of pH and cheap, easy availability makes this technique more powerful than other Solubilization methods. In the present review attempt has been made to provide detailed information on the novel applications of hydrotropy with respect to Cosmeceutical and transdermal formulations as well the mechanism of hydrotropes, hydrotropic agents, classification and Solubilization of hydrotropes, several hydrotropes used in tablet formulation are discussed.
http://ift.tt/2fyRR3s
Τρίτη 8 Νοεμβρίου 2016
MIXED HYDROTROPY: A RISING TOOL FOR SOLUBILITY ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY AND COSMECEUTICAL APPLICATIONS
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182, Butyric Acid from Probiotic Staphyloco...
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης A Novel Technique for Endoscopic Repair of Large Anterior Skull Base Defect...
-
2016-11-22T07-55-59Z Source: International Journal of Medical Science and Public Health Banothu Srinivas, Madhu Mohan Reddy B. Backgrou...
-
2016-10-15T06-30-01Z Source: The Southeast Asian Journal of Case Report and Review Sangita Deepak Kamath, Neeraj Jain, Saurabh Pathak, Ba...
-
BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with cl...
-
Abstract The development of focused ion beam-scanning electron microscopy (FIB-SEM) techniques has allowed high-resolution 3D imaging of n...
-
Vol.48 No.2 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1S2Z7n2 via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου