SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-HETEROCYCLIC SUBSTITUTED HYDRAZONE SCHIFF’S BASES

2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
Vrushali T. Kale*, Archana S. Burghate, Shrikant A. Wadhal.
The present research deals with the synthesis, spectral studies and biological evolution of substituted hydrazone schiffs bases derivatives of benzothiazolyl and benzimidazolyl for antimicrobial activity. the compounds were synthesized by green chemistry technique which includes synthesis series of 2-[1-(Benzothiazole-2-yl hydrazono)-ethyl]-4-methyl phenol 3, 2-(Benzothiazole-2-yl hydrazono)-methyl)- phenol, N-Benzothiazole-2-yl-N-(1-4-chloro-phenyl)-ethylidene]-hydrazine ,2-[1-H-Benzimidazole-2-yl hydrazono)-methyl]-4-methyl phenol and implemented for their antibacterial activity study. The antimicrobial activities of these synthesized compounds are done by agar disc diffusion method at two different concentrations in DMSO against gram positive bacteria Staphylococcus aureus and gram negative bacteria Escherichia coli. Structures of all the newly synthesized compounds were confirmed by their IR, 1H-NMR and CHN analysis .From the synthesized compounds 3a,3b,3c biologically active Escherichia.coli and Staphylococcus. Aureus.


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