3 H-QUINAZOLIN-4-ONES AS ANTICANCER AGENTS: A REVIEW

2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
Nilesh S. Khairnar*, Jogendra C. Hundiwale, Avinash V. Patil.
Heterocyclic chemistry composed of at least fifty percent of all organic chemistry research worldwide which contains heterocyclic moieties. 4(3H)-Quinazolinone is nothing but the 3H-Quinazolin-4-one which play a prominent role in the field of Pharmaceutical Medicinal Chemistry for to invent or discover the new potent moiety. It is strongly showing evidence as active chemical agents in all human being or in animals by their pharmacological activity. 4(3H)-Quinazolinone and their entire derivatives having very good pharmaceutical utility among the influential classes of heterocyclic moieties by synthesizing it through various synthetic avenues. It shows some of the Pharmaceutical or Biochemical activities like anticancer, analgesic & anti-inflammatory, anti HIV, antimicrobial, anticonvulsant, antimalerial & antifungal etc. from the literature survey. Cancer is very crucial or critical health problem now a day in developing as well as undeveloped countries. It has achieved first position as killer by surpassing the heart disease also from all over the world. It is quiet difficult task to design novel antitumor agent in lab level but it is critically very important. The purpose of this review was to follow literature work reported by researchers on 3H-Quinazolin-4-ones for only anticancer activity. This review might be helpful in the development of novel lead molecules which is having heterocyclic nucleus to potential drug profile for future prospect as anticancer agent and become prospective part in fulfillment of pharmaceutical world. Epidermal Growth Factor Receptor (EGFR) is made from one of the erbB members which come from Tyrosine Kinase Receptor (TKR). It is cellular transmemberane glycoprotein.


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