Evaluation of pharmacological and toxicological studies of an ayurvedic medicine Rasaraj Ras on biological system of the male Sprague-Dawley rats

2016-11-19T02-01-43Z
Source: International Journal of Basic & Clinical Pharmacology
Ferdousi Akter, Md. Mamun Sikder, Shemonty Hasan, Mustari Hossain, Massnoon Ali, Manoth Kumer Biswas, Nilay Saha, M. S. K. Choudhuri.
Background: In this study, the pharmacological and toxicological effects along with possible side effects of the classical ayurvedic formulation Rasaraj Ras (RR) which is used as a traditional medicine in the treatment of hemiplegia in the rural population were evaluated. Methods: During this study, various experiments on body growth rate, organ-body weight ratio and tissue hydration indices were performed to evaluate its efficacy and toxicity. To find out the toxicological characteristic of RR, it was administered chronically to the male Sprague-Dawley rats at a dose of 40 mg/kg. After 28 days chronic administration of the RR preparation the following toxicological changes were noted. Results: All throughout the experimental period the RR treated animals were always maintaining negligible changes in body weight, but all throughout the experimental period no statistically significant increase or decrease was noted. There is a statistically significant decrease in the relative percent weight of the male rat heart. There is a statistically highly significant decrease in the absolute weight of the male rat liver. There is a statistically highly significant decrease in the relative percent weight of the male rat liver. There is a statistically significant decrease in the relative percent weight of the male rat kidney. In the tissue hydration index determination, no significant changes were noted in case of any organ. Conclusions: As RR decreases abnormally weight of several organs in body of treated rats, so it should not be administered chronically at a higher dose.


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