Evaluation of changes in rat fatigability and biochemical parameters after oral and intra-peritoneal administration of adenosine tri phosphate: an experimental study

2016-11-19T05-04-49Z
Source: International Journal of Basic & Clinical Pharmacology
Sheshidhar Gajanan Bannale, Sangappa V. Kashinakunti, Manjula Rangappa, Pundarikaksha Hulikallu Purushothama, Yasmeen A. Maniyar, Manjunath Sajjanavar.
Background: Adenosine tri phosphate (ATP) is an important intracellular energy source and has many extracellular functions meadiacating through purine receptors. Currently ATP is available in the market as oral dietary supplement. However there are inconclusive studies regarding its efficacy through oral route. Hence this study was carried out to evaluate efficacy of oral and intraperitoneal administration of ATP in experimental rats by comparing swim exhaust time and associated biochemical changes. Methods: 18 Swiss albino rats of either gender were grouped randomly into three groups, consisting of group -1 control group which receive distilled water (5ml/kg body weight) whereas group 2 and 3 received oral and intraperitoneal ATP (60mg/kg body weight) for 8 days. On 8th day all rats all rats were evaluated for extent of physical fatigue by using exhaustive swimming test time required to attain immobility status is noted. Under aseptic precautions blood samples were drawn from rat tail vein and biochemical parameters like uric acid, triglycerides, total cholesterol, random blood sugar and c-reactive protein levels were measured. Results: There was a significant (p


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