2016-11-19T02-01-43Z
Source: International Journal of Basic & Clinical Pharmacology
Preet Sood, Manmohan Bhanot, Narinder Singh.
Background: Nepafenac is a novel topical NSAID used to treat post operative ocular inflammation and pain. Benzylkonium chloride is used as preservative in the formulation, is notorious in causing ocular surface defect. Now a day, preservative free formulation is available. This study is the comparison of the efficacy and safety of preservative free nepafenac with standard nepafenac eye drop formulation. Methods: This is a prospective investigator masked randomised parallel trial. Total n= 104 patients were enrolled. After randomization, patients were divided into two groups (nepafenac withwithout preservative drug).Patients were examined preoperatively (day-1) and post operatively on days 1, 3, 5, 7, 15 and 30 days. The signs of inflammation and tear film break up time were recorded. Results: preservative free nepafenac was found better at certain points like aqueous cells at day15 (p=0.02), conjunctival hyperemia at day 5 (p=0.009) and pain at day3 (p=0.004) at other points. Effect on tear film breakup time was recorded but it is not statistically significant. Conclusions: preservative free nepafenac is found effective in controlling the ocular post inflammation. For evaluating the effect on dryness of eye we need longer trials. Preservative free nepafenac should be preferred over the nepafenac eye drops.
http://ift.tt/2fOC1ko
Σάββατο 19 Νοεμβρίου 2016
To compare the efficacy and preserved/preservative free nepafenac eye drops in the post cataract inflammation patients
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with cl...
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
Despite widespread journal endorsement of reporting guidelines, the poor reproducibility of preclinical research is increasingly under debat...
-
The benefit of the breastfeeding has been well-established. In comparison to partial breast feeding, exclusive breastfeeding has even more b...
-
A report of the Cold Spring Harbor Laboratory/Wellcome Trust Meeting on Engineering Principles in Biology, Cambridge, UK, 14-16 October 2009...
-
Abstract We report here a microscopic tight-binding theoretical study of the dynamic dielectric response of graphene-on-polarizable substr...
-
Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
-
The “new” silk road—the belt and road initiative (BRI)—is China’s grand idea for the 21st century, promising to transform international deve...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου