IJMS, Vol. 18, Pages 1584: DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

IJMS, Vol. 18, Pages 1584: DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

International Journal of Molecular Sciences doi: 10.3390/ijms18071584

Authors: Elizaveta Boldinova Paulina Wanrooij Evgeniy Shilkin Sjoerd Wanrooij Alena Makarova

PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria.

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