The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos

Publication date: Available online 4 February 2016
Source:Cell Reports
Author(s): Felix Sommer, Marcus Ståhlman, Olga Ilkayeva, Jon M. Arnemo, Jonas Kindberg, Johan Josefsson, Christopher B. Newgard, Ole Fröbert, Fredrik Bäckhed
Hibernation is an adaptation that helps many animals to conserve energy during food shortage in winter. Brown bears double their fat depots during summer and use these stored lipids during hibernation. Although bears seasonally become obese, they remain metabolically healthy. We analyzed the microbiota of free-ranging brown bears during their active phase and hibernation. Compared to the active phase, hibernation microbiota had reduced diversity, reduced levels of Firmicutes and Actinobacteria, and increased levels of Bacteroidetes. Several metabolites involved in lipid metabolism, including triglycerides, cholesterol, and bile acids, were also affected by hibernation. Transplantation of the bear microbiota from summer and winter to germ-free mice transferred some of the seasonal metabolic features and demonstrated that the summer microbiota promoted adiposity without impairing glucose tolerance, suggesting that seasonal variation in the microbiota may contribute to host energy metabolism in the hibernating brown bear.

Graphical abstract

Teaser

Sommer et al. show that the microbiota and serum metabolites in brown bears differ seasonally between hibernation and active phase. Colonization of mice with a bear microbiota promoted increased adiposity. These findings suggest that seasonal microbiota variation may contribute to metabolism of the hibernating brown bear.


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