Source:Cell Reports
Author(s): Naoya Takahashi, Chiaki Kobayashi, Tomoe Ishikawa, Yuji Ikegaya
The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local synaptic excitation and global inhibition in hippocampal pyramidal neurons using functional dendrite imaging in combination with whole-cell recordings of inhibitory postsynaptic currents. We found that the sums of spine inputs over dendritic trees were counterbalanced by a proportional amount of somatic inhibitory inputs. This online E/I correlation was maintained in dendritic segments that were longer than 50 μm. However, at the single spine level, only 22% of the active spines were activated with inhibitory inputs. This inhibition-coupled activity occurred mainly in the spines with large heads. These results shed light on a microscopic E/I-balancing mechanism that operates at selected synapses and that may increase the accuracy of neural information.
Graphical abstract
Teaser
Takahashi et al. find that, although global GABAergic inhibition counterbalances synaptic excitation on dendritic trees, this balance breaks down at the microscopic level since only large synapses are excited by this inhibition.from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PWoe4G
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου