Purpose The aim of this study was to assess the clinical feasibility, image quality, and radiation dose implications of 0.25-mm imaging mode in a cohort of humans, achieved by dividing the photon-counting detector (PCD) size in half compared with standard-resolution photon-counting computed tomography (CT) (0.5 mm). Methods In this technical feasibility study, a whole-body prototype PCD-CT scanner was studied in the 0.25 mm detector mode (measured at isocenter). A high-resolution PCD-CT protocol was first tested in phantom and canine studies in terms of image noise and spatial resolution. Then, 8 human subjects (mean age, 58 ± 8 years; 2 men) underwent axial PCD 0.25-mm scans of the brain, the thorax, and at the level of the upper left kidney. Filtered backprojection reconstruction was performed with a sharp kernel (B70) for standard-resolution and high-resolution data at 0.5-mm isotropic image voxel. High-resolution data, in addition, were reconstructed with an ultrasharp kernel (U70) at 0.25-mm isotropic voxels. Results Image reconstructions from the PCD 0.25-mm detector system led to an improvement in resolution from 9 to 18 line pairs/cm in a line pair phantom. Modulation transfer function improved from 9.5 to 15.8 line pairs/cm at 10% modulation transfer function. When fully exploiting this improvement, image noise increased by 75% compared with dose-matched 0.5-mm slice PCD standard-resolution acquisition. However, when comparing with standard-resolution data at same in-plane resolution and slice thickness, the PCD 0.25-mm detector mode showed 19% less image noise in phantom, animal, and human scans. Conclusion High-resolution photon-counting CT in humans showed improved image quality in terms of spatial resolution and image noise compared with standard-resolution photon-counting. Received for publication November 13, 2017; and accepted for publication, after revision, January 10, 2018. Conflicts of interest and sources of funding: This study was supported by the NIH Intramural Research Program and a collaborative research agreement with Siemens Healthcare GmbH (Forchheim, Germany). Data inclusion and analysis was performed by the authors who are not employees of or consultants for Siemens. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (https://ift.tt/2kq7jVD). Correspondence to: Amir Pourmorteza, PhD, Department of Radiology and Imaging Sciences, Winship Cancer Institute of Emory University, 1701 Uppergate Drive, Suite 5018A, Atlanta, GA 30322. E-mail: amir.pourmorteza@emory.edu. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
from Imaging via alkiviadis.1961 on Inoreader https://ift.tt/2GBkix1
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation...
-
Abstract Purpose Overcoming the flaws of current data management conditions in head and neck oncology could enable integrated informatio...
-
A middle-aged poorly controlled diabetic man developed left-sided orbital and facial swelling several days after extraction of a left upper ...
-
Universal newborn hearing screening (UNHS) has become the standard of care in many countries. The aim of this study was to evaluate the resu...
-
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of lichen sclerosus (LS)...
-
Abstract The head-mounted display (HMD) has the potential to improve the quality of ultrasound-guided procedures. The aim of this non-clin...
-
http://ift.tt/2pnwWaQ
-
Background. Globally 3 to 8% of reproductive age women are suffering from premenstrual dysphoric disorder (PMDD). Several mental and reprodu...
-
ACS Nano DOI: 10.1021/acsnano.7b01926 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pOw4te via...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου