Publication date: Available online 28 March 2018
Source:Current Problems in Diagnostic Radiology
Author(s): Basak Dogan, Qing Yuan, Roland Bassett, Inanc Guvenc, Edward F. Jackson, Massimo Cristofanilli, Gary J. Whitman
PurposeTo compare the value of dynamic contrast-enhanced MRI (DCE-MRI)-pharmacokinetic (PK) parameters versus tumor volume in predicting breast cancer neoadjuvant chemotherapy response (NACR) and patient survival.Subjects and MethodsSixty-six patients with locally advanced breast cancer who underwent breast MRI monitoring of NACR were retrospectively analyzed. We compared baseline transfer constant (Ktrans), reflux rate contrast (kep), and extracellular extravascular volume fraction (ve) with the same parameters obtained at early post-chemotherapy MRI, and examined model-independent changes in time-intensity curves (maximum slope, contrast enhancement ratio, and IAUC90). Tumor size changes (tumor volume, single dimension, and RECIST) were also analyzed. The Spearman correlation test was used to assess the association between size and PK parameters, and regression analysis to assess the association with 5-year disease free survival.ResultsHigher ve values at baseline were associated with greater decreases in tumor size (P=0.008). Changes in Ktrans and IAUC90 were the strongest predictors of NACR. Changes in IAUC90 (P=0.04) and RECIST (P=0.003) were independently associated with pathological response. The only parameter significantly associated with 5-year survival was change in RECIST (P=0.001). However, there was a trend toward statistical significance for changes in ve and Ktrans, with greater changes associated with longer survival.ConclusionChanges in PK and DCE-MRI kinetic parameters may have a role in predicting NACR in breast tumors. While changes in Ktrans and IAUC90 are helpful in predicting NACR, they do not show significant association with survival. Early RECIST size change measured by MRI remains the strongest predictor of overall patient survival.
from Imaging via alkiviadis.1961 on Inoreader https://ift.tt/2GfMFBL
Τετάρτη 28 Μαρτίου 2018
Comparing the performances of Magnetic Resonance Imaging size versus pharmacokinetic parameters to predict response to neoadjuvant chemotherapy and survival in breast cancer patients
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Objectives Adult sagittal posture is established during childhood and adolescence. A flattened or hypercurved spine is associated with poore...
-
Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation...
-
Abstract Purpose Overcoming the flaws of current data management conditions in head and neck oncology could enable integrated informatio...
-
CBN News Cancer Took Most of His Tongue, but This Pastor Is Still Singing ... CBN News A youth pastor in San Diego, California is not ...
-
Family: Know the drill New Straits Times Online One of my sons had this so often that his tonsils were removed. ... However, for som...
-
The E3 ubiquitin ligase F-box and WD repeat domain containing 7 (FBW7α) functions as a putative tumor suppressor in non-small cell lung canc...
-
In this study, the changes in pH, organic acid content, acidity, and salinity of kimchi prepared at 0 days, stored 1–8 weeks at 4 and 10°C, ...
-
When you make pizza this good you are allowed to brag about it. Come try a square of the best pizza in Erie. Ohhh yeah, we have ice cream no...
-
The March for Science reflects the growing gap between slow, steady, vital scientific gains and quick-fire, opportunist US politics, says D...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου