Iridium-Catalyzed Enantioselective Hydrogenation of Vinylsilanes

We have screened a diverse array of iridium complexes derived from chiral N,P ligands as catalysts for the asymmetric hydrogenation of vinylsilanes, a transformation for which generally applicable catalysts were lacking. Several catalysts emerged from this study that enabled the highly enantioselective hydrogenation of a wide range of vinylsilanes with trisubstituted or disubstituted terminal C=C bonds bearing aryl, alkyl, ethoxycarbonyl, or hydroxymethyl substituents. In addition to trimethylsilyl and dimethyl(phenyl) silyl derivatives, trialkoxysilyl- and silacyclobutyl-substituted alkenes were used as substrates.

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