Effects of exercise training on restless legs syndrome, depression, sleep quality and fatigue among hemodialysis patients: A systematic review and meta-analysis.

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Effects of exercise training on restless legs syndrome, depression, sleep quality and fatigue among hemodialysis patients: A systematic review and meta-analysis.

J Pain Symptom Manage. 2017 Dec 13;:

Authors: Song YY, Hu RJ, Diao YS, Chen L, Jiang XL

Abstract
CONTEXT: Hemodialysis patients experience a heavy symptom burden that leads to a decreased quality of life. Pharmacological treatment is effective but costly and has adverse effects. Exercise is a promising approach for symptom management, but the effect of exercise on restless legs syndrome, depression, sleep quality and fatigue in hemodialysis patients is still uncertain.
OBJECTIVES: This meta-analysis was conducted to identify whether exercise training is beneficial in the treatment of the symptoms of restless legs syndrome, depression, poor sleep quality, and fatigue in patients receiving hemodialysis.
METHODS: A systematic search of PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science was conducted to identify randomized controlled trials (RCTs) comparing exercise training with routine care on restless legs syndrome, depression, sleep quality and fatigue among hemodialysis patients. Quality assessment was conducted using the Cochrane risk of bias tool, and RevMan (5.3) was used to analyze the data.
RESULTS: Fifteen RCTs met our inclusion criteria were included. The pooled effect size showed that exercise training was effective on restless legs syndrome (P<0.001), depression (P<0.001) and fatigue (P<0.001). However, effect size combinations for sleep quality were not performed due to the sensitivity analysis results.
CONCLUSIONS: Exercise training may help hemodialysis patients to reduce the severity of restless legs syndrome, depression, and fatigue. More high-quality RCTs with larger samples and comparative RCTs focused on different exercise regimens are needed.

PMID: 29247753 [PubMed - as supplied by publisher]

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