Multifocal occurrence of intraoral isolated MS in a patient without leukemic presentation: a case report and literature review

Publication date: Available online 22 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Yanxin Shen, Lei Zhao, Yafei Wu, Ping Huang
Myeloid sarcoma (MS), also referred to as chloroma or granulocytic sarcoma, is a rare extramedullary malignant tumor composed of immature myeloid cells. MS usually occurs with acute myelocytic leukemia (AML), myeloproliferative neoplasm, or myelodysplastic syndrome, or as a recurrence of AML; however, MS may occasionally present isolated, without current or previous peripheral blood or bone marrow involvement. The oral and maxillofacial MS, especially isolated, is extremely rare, and the clinical manifestations are diverse and usually non-specific. Here we report a rare case of isolated nonleukemic MS involving the gingivae, mucosa of the left maxillary edentulate region and the adjacent hard palate. The pertinent literature was also reviewed to provide additional clarification on the clinicopathologic characteristics, differential diagnosis, treatment regimens and prognosis of oral and maxillofacial isolated MS.



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