The use of gadolinium-based contrast agents in MR images has become one of radiology's most debated topic. In a study published in Radiology, a manganese-based contrast agent, manganese-N-picolyl-N,N',N'-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) is shown enable contrast-enhanced MR angiography with comparable contrast enhancement to gadolinium-based agents and may overcome concerns regarding gadolinium-associated toxicity and retention. Eric M. Gale et al compared contrast material–enhanced MR angiography in baboons by using Mn-PyC3A and Gd-DTPA.
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