The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer

by Fangxuan Li, Yuenan Guo, Juntian Liu, Rupeng Zhang

Objective

Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC.

Methods

Based on 65 pairs matched GC patients and health controls, we explored clinical significance of miR 106b~25 for GC and compared their diagnostic performance with conventional tumor biomarkers including CA724, CA242, CA199 and CEA.

Results

Both miR 106b~25 cluster and conventional tumor biomarkers were significantly elevated in GC (All PP Conclusions

Plasma miR 106b~25 cluster, especially miR 106b, were significantly increased in GC patients and may be hopeful diagnostic biomarkers.

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