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We thank Dr Miller for his letter1 in response to our recent Rostrum article in the Journal.2 We agree that there is a strong body of literature linking advanced glycation end products (AGEs) in the diet and diseases such as atherosclerosis, renal failure, cataracts, and forms of dementia such as Parkinson disease and Alzheimer disease.3-5 The focus of our article was to point out that increase in dietary AGEs and sugars (particularly fructose), which leads to the formation of AGEs, appears to have epidemiological associations with the rise of severe food allergy and there are laboratory correlates showing that the activation of the receptor for advanced glycation end products (RAGE) has pivotal roles in allergic inflammation.

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