The excellent review by Smith et al1 makes a convincing case for the contribution of dietary advanced glycation end products (AGEs) to the development of food allergy. There is also additional evidence that AGEs may be involved in asthma. Induced sputum levels of the AGE pentosidine are higher in patients with asthma than in those without asthma, and increase with age at a markedly faster rate in patients with asthma than in controls, such that they are higher in young patients with asthma than in old people without asthma.
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