A new large-scale genetic research study led by researchers from the International Agency for Research on Cancer (IARC) has identified elevated body mass index (BMI) and increased fasting insulin levels as causal risk factors for pancreatic cancer. The researchers also provided intriguing new evidence on the mechanistic pathways that may play a role, in particular for insulin-related pathways. Pancreatic cancer is one of the most lethal cancers, with 5-year survival rates of about 5%. Therefore, the identification of modifiable risk factors can play a critical role in informing preventive measures.
Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, et al.
The role of obesity, type 2 diabetes, and metabolic factors in pancreatic cancer: a Mendelian randomization study
J Natl Cancer Inst. Published online 28 April 2017; http://ift.tt/2pNELG9
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pNrz4k
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Family: Know the drill New Straits Times Online One of my sons had this so often that his tonsils were removed. ... However, for som...
-
UM-Chor1: establishment and characterization of the first validated clival chordoma cell line. J Neurosurg. 2017 Apr 21;:1-9 Authors:...
-
Publication date: Available online 10 May 2017 Source: Journal of Dairy Science Author(s): R.E. Vibart, M. Tavendale, D. Otter, B.H. Schw...
-
Abstract Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer’s disease (AD) neuropathology. In this study, w...
-
Related Articles Developmental control of macrophage function. Curr Opin Immunol. 2017 Dec 13;50:64-74 Authors: Bonnardel J, Guillia...
-
Description A Caucasian boy aged 5 years presented with acute onset of a non-tender, palpable purpuric rash to his lower limbs, preceded by ...
-
Purpose. Sinonasal malignant mucosal melanoma is a rare, aggressive tumour. Nasal obstruction and epistaxis are the most commonly reported s...
-
Abstract Conquering immunosuppression in tumor microenvironments is crucial for effective cancer immunotherapy. It is well known that inte...
-
Abstract: Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal e...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου