Multi-isotope SPECT imaging of the 225 Ac decay chain: feasibility studies

Effective use of the ##IMG## [http://ift.tt/2q7e0xx] {${}^{225}{\rm Ac}$} decay chain in targeted internal radioimmunotherapy requires the retention of both ##IMG## [http://ift.tt/2pNShYc] {${}^{225}{\rm Ac}$} and progeny isotopes at the target site. Imaging-based pharmacokinetic tests of these pharmaceuticals must therefore separately yet simultaneously image multiple isotopes that may not be colocalized despite being part of the same decay chain. This work presents feasibility studies demonstrating the ability of a microSPECT/CT scanner equipped with a high energy collimator to simultaneously image two components of the ##IMG## [http://ift.tt/2q6MDDM] {${}^{225}{\rm Ac}$} decay chain: ##IMG## [http://ift.tt/2pNZt73...] {${}^{221}{\rm Fr}$}

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